There are many many characters but the "big 7" have always been Torg, Riff, Zoe, Gwynn, BunBun, Aylee, and Kiki, albeit Kiki's significance has always been secondary to the rest.

In my mind the "Tier-2" level characters are Schlock, Oasis, Kusari, K'Z'K, Sasha (RIP), and Sam (his story could probably be considered done).

There's also the Tier 2.5/3 - the Zalias, Teresa, Strom, Torg's other chessmen, the Chilus(Tombsy?) cult, and the hC inner circle.

Would Calix & Kada Jansen count as 3rd tier?

Edit
I think Drake & Tyler are going to return too.

Given the spider that was crawling around the last time that we saw Sam, I don't think we're done with him yet...

And then 4th tier would be the holidays/gods. Don't count them out! We wouldn't have the black ops elves otherwise. Or Chad

I think the Torgamus from the Stormbreaker saga was an alternate reality Torg. Possibly even the one from the DoL, which would explain why that Riff never found him and settled for the Torg from the Dimension of Jerks. Only DoR Riffs have the advanced technology to peer into the historical timelines of other dimensions. So at this moment, I can't predict anyone of the main group dying besides Oasis. I mean you can make a case for all of them, certainly, but the story isn't really at a point where any of them are narratively doomed.

The problem with those four is that we don't really know, aside from the obvious connection to Bun-Bun for Calix and Kada, where they actually fit. I'd love to see all four of them again, but I don't think we'll ever see Drake and Tyler again, at least not doing anything useful.

I do think depending on what happens with hC in the next "day" (which might start next week?) we might end up seeing Calix and Kada again sooner rather than later.

With Drake & Tyler they both had symbols on their clothing which reminded me of the symbols of the gods of Mokadun.
Tyler was a sideways hourglass and Drake has a dash within brackets. Handy link.

Until Tyler's trip to Timeless space I had written off Calix & Kada. Not knowing the happenings/time differences Calix sould have an armada

I predict that Riff will not blame Torg for Sasha's death and it will not drive a further wedge between them. Rather, this event will finally allow them to understand each other's perspective re: monsters/friends and what happens when the two are the same.

I like your spec! I hope it is true. I can see some hints leading that way. Certainly, the echoes of Torg's in-transit reaction to Sam's death in the strip today, and their shared expressions point that way.

I think Drake's hat symbol is supposed to be chain links.
Personally I view their story as being complete, but much like Sam I wouldn't mind seeing them pop up again.

Anyway, I expect to see La'Mort paying their casino a visit pretty soon. Or HeretiCorp, whichever she fancies more. There's just no way all those shenanigans went down just outside her house and she missed it all. Plus we need another wrench before Torg and Riff's terrible plan that's doomed to fail is enacted.

[edit] I also want to see La'Mort again because I'm dying to find out whether or not my spec about her is right! C'moooon!
(but not dying nearly as hard as Torg and Riff are about to)

I can only guess that now Riff has the nanites...or I guess the radiation caused by them.

And so, the assault on HC has become the assault on the Casino, and Schlock finally wins.

Everybody dies, including Oasis. But realy, who cares? She's just gonna come back again.

That wraps up the 20 year story, everyone! Stay tuned for sluggy 20+ with "The Crazy Adventures of Schlock and Kusari: True Love's Kiss."

Which would only matter in the short term if their base of operations is in Washington DC.

Possibly, but I'm thinking more panels 1/2 here: http://www.sluggy.com/comics/archives/daily/20170609

We still don't know Sasha's "info", but now thinking about others suggestions. Hmm.... possibly Sasha was sent as the sacrificial lamb in the vain hope she'd get to tussle with Oasis. After the long hotel scene I'm on the edge of my seat again

What range/control/conditions do they have on the 'infected' people. Do they have to be on scan range or can they pop them anywhere via satellite, WiFi, etc?

If I recall correctly Riff has been radioactive for years. I'm sure I saw some reference regarding isotopes and his wallet (exploding?). Then the mellow yellow mini nuclear reactor *cough* decommissioned suitcase bomb *cough* and the time in New Jersey at Gwynn's old house.